Diagnosing necrolytic acral erythema

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Necrolytic Acral Erythema in Seronegative Hepatitis C

Necrolytic acral erythema (NAE) is a distinctive skin disorder. The exact cause and pathogenesis is still unclear. Most studies report an association of NAE with hepatitis C virus (HCV) infection. We report a 64-year-old woman who presented with chronic mildly pruritic brownish to erythematous rashes on both lateral malleoli for 7 months. The clinical and histopathological findings were compati...

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Successful Treatment of Necrolytic Acral Erythema with Ledipasvir and Sofosbuvir

Importance: Necrolytic Acral Erythema (NAE) is a cutaneous manifestation of hepatitis C virus infection, characterized by painful, unsightly lesions that tremendously diminish quality of life. Currently available treatments are minimally effective or difficult to tolerate. Additionally, interferon alpha, the most effective treatment to date, is contraindicated in patients with autoimmune diseas...

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Necrolytic acral erythema: a rare skin disease associated with hepatitis C virus infection*

Necrolytic acral erythema is a rare skin disease associated with hepatitis C virus infection. We report a case of a 31-year-old woman with hepatitis C virus infection and decreased zinc serum level. Physical examination revealed scaly, lichenified plaques, well-demarcated with an erythematous peripheral rim located on the lower limbs. After blood transfusion and oral zinc supplementation the pa...

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Necrolytic acral erythema: a patient from the United States successfully treated with oral zinc.

BACKGROUND Recently, necrolytic acral erythema (NAE) has been described as a cutaneous marker for hepatitis C virus (HCV) infection. Only 2 cases have been reported in the United States. Successful remission has been induced only with interferon therapy with or without ribavirin. OBSERVATIONS We describe a 46-year-old, HCV-positive African American woman with well-defined, dusky, erythematous...

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Necrolytic acral erythema associated with hepatitis C: effective treatment with interferon alfa and zinc.

BACKGROUND Necrolytic acral erythema is a recently described necrolytic erythema that is unique in its exclusive acral location and strong association with hepatitis C. OBSERVATION We report the first case of necrolytic acral erythema in the United States. The patient is a 43-year-old black woman who presented with a 4-year history of tender, flaccid blisters localized to the dorsal aspect of...

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ژورنال

عنوان ژورنال: Indian Journal of Dermatology

سال: 2011

ISSN: 0019-5154

DOI: 10.4103/0019-5154.80448